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Biaryl Synthesis via Direct Arylation: Establishment of an Efficient Catalyst for Intramolecular Processes

Louis-Charles Campeau, Mathieu Parisien, Melissa Leblanc and Keith Fagnou*

*Center for Catalysis Research and Innovation, University of Ottawa, Department of Chemistry, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5, Email: keith.fagnouscience.uottawa.ca

L.-C. Campeau, M. Parisien, M. Leblanc, K. Fagnou, J. Am. Chem. Soc., 2004, 126, 9186-9187.

DOI: 10.1021/ja049017y (free Supporting Information)


Abstract

A direct Pd-catalyzed arylation reaction for the intramolecular formation of biaryl compounds using a novel phosphine ligand offers enhanced catalytic activity for transformations of previously unreactive substrates.

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Key Words

Biaryls, benzo-fused O-Heterocycles, Lactams


ID: J48-Y2004-1600