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Catalytic Enantioselective Conjugate Addition of Carbamates

Claudio Palomo,* Mikel Oiarbide, Rajkumar Halder, Michael Kelso, Enrique Gómez-Bengoa and Jesús M. García

*Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain, Email: claudio.palomoehu.es

C. Palomo, M. Oiarbide, R. Halder, M. Kelso, E. Gómez-Bengoa, J. M. García, J. Am. Chem. Soc., 2004, 126, 9188-9189.

DOI: 10.1021/ja047004e (free Supporting Information)


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Abstract

A catalytic, asymmetric conjugate addition of carbamates to enoyl systems provides a highly enantioselective two-step access to N-protected β-amino acids.

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Key Words

β-Amino Ketones, β-Amino Acids, Oxidative Cleavage, Sodium Periodat


ID: J48-Y2004-1610