New Protocol for Efficient N-Chlorinations of Amides and Carbamates
Oleg V. Larionov, Sergei I. Kozhushkov, Armin de Meijere*
*Institut für Organische Chemie der Georg-August-Universität Göttingen,
Tammannstrasse 2, 37077 Göttingen, Germany, Email: Armin.deMeijere
chemie.uni-goettingen.de
O. V. Larionov, S. I. Kozhushkov, A. de Meijere, Synthesis, 2003, 1916-1919.
DOI: 10.1055/s-2003-41037
Abstract
N-Chlorination of various amides, carbamates and lactams with inexpensive and stable calcium hypochlorite on moist alumina proceeds smoothly and efficiently. Excellent results were also observed for the N-chlorination of protected amino acid esters with a cyclopropane moiety.
see article for more examples
Key Words
amides, amino acids, N-chlorination, calcium hypochlorite, alumina
ID: J66-Y2003-1950
