Organic Chemistry Portal

Abstracts

Search:

Palladium-Catalyzed Oxygenation of Unactivated sp3 C-H Bonds

Lopa V. Desai, Kami L. Hull and Melanie S. Sanford*

*Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, Email: mssanforumich.edu

L. V. Desai, K. L . Hull, M. S. Sanford, J. Am. Chem. Soc., 2004, 126, 9542-9543.

DOI: 10.1021/ja046831c (free Supporting Information)


Abstract

A new palladium-catalyzed method allows the oxygenation of unactivated sp3 C-H bonds of a wide variety of alkane substrates containing readily available oxime and/or pyridine directing groups with extremely high levels of chemo-, regio-, and in some cases diastereoselectivity.

see article for more reactions



Key Words

β-hydroxy carbonyl compounds, esters, iodosobenzene diacetate


ID: J48-Y2004-1650