Synthesis of Vinyl Sulfonamides Using the Horner Reaction
Deborah C. Reuter*, Joel E. McIntosh, Ashley C. Guinn, Ann Marie Madera
*Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Ave. R6E-3, Palo Alto, CA 94304, USA, Email: deborah.reuterroche.com
D. C. Reuter, J. E. McIntosh, A. C. Guinn, A. M. Madera, Synthesis, 2003, 2321-2324.
A series of vinyl sulfonamides was synthesized using the Horner reaction of aldehydes and diphenylphosphorylmethanesulfonamide. The sulfonamide reagent was easily prepared and can be stored indefinitely.
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