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Decarboxylative Aldol Reactions of Allyl β-Keto Esters via Heterobimetallic Catalysis

Sha Lou, John A. Westbrook and Scott E. Schaus*

*Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, Email: seschausbu.edu

S. Lou, J. A. Westbrook, S. E. Schaus, J. Am. Chem. Soc., 2004, 126, 11440-11441.

DOI: 10.1021/ja045981k (free Supporting Information)


Abstract

Mild and selective heterobimetallic-catalyzed decarboxylative aldol reactions of allyl β-keto esters with aldehydes are promoted by Pd(0)- and Yb(III)-DIOP complexes at room temperature. The optimized reaction conditions require the addition of both metals.

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Key Words

β-hydroxy ketones, decarboxylation


ID: J48-Y2004-1710