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Catalytic, Highly Enantio- and Diastereoselective Pinacol Coupling Reaction with a New Tethered Bis(8-quinolinolato) Ligand

Norito Takenaka, Guoyao Xia and Hisashi Yamamoto*

*Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, Email: yamamotouchicago.edu

N. Takenaka, G. Xia, H. Yamamoto, J. Am. Chem. Soc., 2004, 126, 13198-13199.

DOI: 10.1021/ja045430u (free Supporting Information)


Abstract

A chromium complex of a chiral, tethered bis(8-quinolinol), effectively catalyzes the pinacol coupling reaction of aromatic aldehydes at room temperature with high yield, high diastereoselectivity, and high enantioselectivity.

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Key Words

pinacol coupling


ID: J48-Y2004-1760