A Convenient Method for Preparing Aromatic α,β-Unsaturated Ketones from α,β-Unsaturated Acyl Chlorides and Arylboronic Acids via Suzuki-Miyaura Type Coupling Reaction

Yoshio Urawa*, Katsutoshi Nishiura, Shigeru Souda, Katsuyuki Ogura

*Process Research Laboratories, Eisai Co., Ltd, 22-Sunayama, Hasaki-machi, Kashima-gun, Ibaraki 314-0255, Japan, Email: y-urawahhc.eisai.co.jp

Y. Urawa, K. Nishiura, S. Souda, K. Ogura, Synthesis, 2003, 2882-2885.

DOI: 10.1055/s-2003-44347

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Abstract

Aromatic α,β-unsaturated ketones are synthesized efficiently by palladium-catalyzed cross-coupling reaction of arylboronic acids with α,β-unsaturated acyl chlorides in the presence of K₃PO₄ hydrate in toluene.

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Key Words

boron, catalysis, cross-coupling, Suzuki coupling, ketones, enones, arenes, palladium

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ID: J66-Y2003-2170