Further Improvements of the Synthesis of Alkynes from Aldehydes
Gerald J. Roth*, Bernd Liepold, Stephan G. Müller, Hans Jürgen Bestmann
*Institut für Organische Chemie der Universität Erlangen-Nürnberg,
Henkestraße 42, 91054 Erlangen, Germany, Email: gerald.roth
bc.boehringer-ingelheim.com
G. J. Roth, B. Liepold, S. G. Müller, H. J. Bestmann, Synthesis, 2004, 59-62.
DOI: 10.1055/s-2003-44346
see article for more reactions
Abstract
A highly convenient way to perform the synthesis of alkynes from aldehydes utilizes a new in situ preparation of dimethyldiazomethylphosphonate. As a consequence a commercially available reagent can now be used, circumventing a disadvantage of earlier protocols.
see article for more examples
An Improved One-pot Procedure for the Synthesis of Alkynes from Aldehydes
S. Müller, B. Liepold, G. J. Roth, H. J. Bestmann, Synlett, 1996, 521-522.
Key Words
terminal alkynes, phosphonates, rearrangements, Seyferth-Gilbert Homologation, Bestmann-Ohira Reagent
ID: J66-Y2004-1840
