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A Unique Catalyst Effects the Rapid Room-Temperature Cross-Coupling of Organozinc Reagents with Carboxylic Acid Fluorides, Chlorides, Anhydrides, and Thioesters

Yongda Zhang and Tomislav Rovis*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80526, Email: rovislamar.colostate.edu

Y. Zhang, T. Rovis, J. Am. Chem. Soc., 2004, 126, 15964-15965.

DOI: 10.1021/ja044113k (free Supporting Information)


Abstract

A new Ni catalyst is capable of effecting the rapid cross-coupling of acid fluorides, acid chlorides, acyl cyanides, anhydrides, thioesters, and pyridyl esters with both groups of diorganozinc reagents. Reactions with acid fluorides as electrophilic partners tolerate epimerizable functionality as well as leaving groups.


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Key Words

Ketones, Aryl ketones, Acyl Fluorides


ID: J48-Y2004-1890