Organic Reactions in Ionic liquids: N-Alkylation of Phthalimide and Several Nitrogen Heterocycles
Zhang-Gao Le, Zhen-Chu Chen*, Yi Hu, Qin-Guo Zheng
*Department of Chemistry, Zhejiang University (xi xi campus), Hangzhou,
310028, P. R. China, Email: zhenchuc
mail.hz.zj.cn
Z.-G. Le, Z.-C. Chen, Y. Hu, Q.-G. Zheng, Synthesis, 2004, 208-212.
DOI: 10.1055/s-2003-44383
see article for more reactions
see article for more examples
Abstract
A convenient, efficient, and selective N-Alkylation of N-acidic heterocyclic compounds with alkyl halides is accomplished in ionic liquids in the presence of potassium hydroxide as a base. In this manner, phthalimide, indole, benzimidazole, and succinimide can be successfully alkylated.
see article for more examples
Organic Reactions in Ionic Liquids: A Simple and Highly Regioselective N-Substitution of Pyrrole
Z.-G. Lea, Z.-C. Chen, Y. Hu, Q.-G. Zheng Synthesis, 2004, 1951-1954.
Key Words
ionic liquids, N-alkylation, imides, Gabriel synthesis, Phthalimides
ID: J66-Y2004-1920
