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Nickel-Catalyzed Cross-Coupling Reaction of Aryl Fluorides and Chlorides with Grignard Reagents under Nickel/Magnesium Bimetallic Cooperation

Naohiko Yoshikai, Hiroko Mashima and Eiichi Nakamura*

*Department of Chemistry, The University of Tokyo, and Nakamura Functional Carbon Cluster Project, ERATO, Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan, Email: nakamurachem.s.u-tokyo.ac.jp

N. Yoshikai, H. Mashima, E. Nakamura, J. Am. Chem. Soc., 2005, 127, 17978-17979.

DOI: 10.1021/ja056327n (free Supporting Information)


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Abstract

Nickel-catalyzed cross-coupling of Grignard reagents with aryl fluorides or chlorides can be achieved efficiently in the presence of a new triarylphosphine ligand. The high reactivity and the unique chemoselectivity of the catalysis have been attributed to synergy of nickel and magnesium atoms preorganized on the ligand.

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Hydroxyphosphine Ligand for Nickel-Catalyzed Cross-Coupling through Nickel/Magnesium Bimetallic Cooperation

N. Yoshikai, H. Matsuda, E. Nakamura, J. Am. Chem. Soc., 2009, 131, 9590-9599.


Key Words

Kumada Coupling, Biaryls, Fluoroarenes


ID: J48-Y2005-2760