Conjugate Additions of α,β-Unsaturated Ketones with Arylzinc Species That Form in situ from Diethylzinc and Arylboronic Acids
Lin Dong, Yan-Jun Xu, Liu-Zhu Gong*, Ai-Qiao Mi, Yao-Zhong Jiang
*Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic
Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P. R. China, Email:
gonglz
cioc.ac.cn
L. Dong, Y.-J. Xu, L.-Z. Gong, A.-Q. Mi, Y.-Z. Jiang, Synthesis, 2004, 1015-1020.
DOI: 10.1055/s-2004-822339
Abstract
Conjugate addition of α,β-unsaturated ketones with arylzinc species, that were formed in situ from diethylzinc and a series of arylboronic acids by boron-zinc exchange reactions, gave 1,4-addition products in good yields.
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Key Words
conjugate addition, α,β-unsaturated ketone, arylboronic acid, boron-zinc exchange reaction
ID: J66-Y2004-2060
