Detritylation of N-Tritylamines via a Naphthalene-Catalyzed Lithiation Process
Cherif Behloul, David Guijarro, Miguel Yus*
*Departamento de Química Orgánica, Facultad de Ciencias and Instituto de
Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante,
Spain, Email: yus
ua.es
C. Behloul, D. Guijarro, M. Yus, Synthesis, 2004, 1274-1280.
DOI: 10.1055/s-2004-822358
Abstract
The reaction of aliphatic and aromatic secondary and tertiary N-tritylamines with lithium powder and a catalytic amount of naphthalene led to reductive detritylation affording the corresponding amines in good yields. The trityl group could selectively be removed in the presence of an allyl or a benzyl group.
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Key Words
tritylamine, lithium, lithiation, detritylation, reductive cleavage
ID: J66-Y2004-2080
