Clean and efficient microwave-solvent-free conversion of homochiral amines, α-amino alcohols and α-amino acids to their chiral 2-substituted pyrrole derivatives
Feray Aydogan and Ayhan S. Demir*
*Department of Chemistry, Middle East Technical University, 06531 Ankara,
Turkey, Email: asdemir
metu.edu.tr
F. Aydogan, A. S. Demir, Tetrahedron, 2005, 61, 3019-3023.
DOI: 10.1016/j.tet.2005.01.120
Abstract
An efficient, solvent-free, microwave-assisted coupling of chloroenones and amines on the surface of silica gel gave 1,2-disubstituted homochiral pyrroles in good yields.
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reaction pathway
Key Words
Pyrroles, Microwave, Silica gel, Chloroenones
ID: J72-Y2005-2870
