Direct and indirect reductive amination of aldehydes and ketones with solid acid-activated sodium borohydride under solvent-free conditions
Byung Tae Cho* and Sang Kyu Kang
*Department of Chemistry, Hallym University, Chuncheon, Kangwondo 200-702,
Republic of Korea, Email: btcho
hallym.ac.kr
B. T. Cho, S. K. Kang, Tetrahedron, 2005, 61, 5725-5734.
DOI: 10.1016/j.tet.2005.04.039
see article for more examples
Abstract
A simple and convenient procedure allows the reductive amination of aldehydes and ketones using sodium borohydride as reducing agent and boric acid, p-toluenesulfonic acid monohydrate or benzoic acid as activator under solvent-free conditions.
see article for more reactions
see article for more examples
Key Words
Reductive amination, Imines (Reductions), Solvent-free reaction, Sodium borohydride
ID: J72-Y2005-2940
