Ionic Liquids-Promoted Multi-Component Reaction: Green Approach for Highly Substituted 2-Aminofuran Derivatives
J. S. Yadav*, B. V. Subba Reddy, S. Shubashree, K. Sadashiv, Jaisree J. Naidu
*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email: yadavpubiict.res.in
J. S. Yadav, B. V. S. Reddy, S. Shubashree, K. Sadashiv, J. J. Naidu, Synthesis, 2004, 2376-2380.
The three-component coupling of aldehyde, dimethyl acetylenedicarboxylate (DMAD) and cyclohexyl isocyanide proceeds efficiently in [bmim]BF4 ionic medium under extremely mild conditions to afford 2-aminofurans in high yields. The recovered ionic liquid was reused for five to six times with consistent activity.
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