Ionic Liquids-Promoted Multi-Component Reaction: Green Approach for Highly Substituted 2-Aminofuran Derivatives

J. S. Yadav*, B. V. Subba Reddy, S. Shubashree, K. Sadashiv, Jaisree J. Naidu

*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email: yadavpubiict.res.in

J. S. Yadav, B. V. S. Reddy, S. Shubashree, K. Sadashiv, J. J. Naidu, Synthesis, 2004, 2376-2380.

DOI: 10.1055/s-2004-831181

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Abstract

The three-component coupling of aldehyde, dimethyl acetylenedicarboxylate (DMAD) and cyclohexyl isocyanide proceeds efficiently in [bmim]BF₄ ionic medium under extremely mild conditions to afford 2-aminofurans in high yields. The recovered ionic liquid was reused for five to six times with consistent activity.

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proposed mechanism

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Key Words

ionic liquids (ILs), multi-component reaction, furan derivatives

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ID: J66-Y2004-2330