Silver Phosphotungstate: A Novel and Recyclable Heteropoly Acid for Friedländer Quinoline Synthesis

J. S. Yadav*, B. V. S. Reddy, P. Sreedhar, R. Srinivasa Rao, K. Nagaiah

*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email: yadaviict.res.in

J. S. Yadav, B. V. S. Reddy, P. Sreedhar, R. S. Rao, K. Nagaiah, Synthesis, 2004, 2381-2385.

DOI: 10.1055/s-2004-831185

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Abstract

o-Aminoaryl ketones undergo a smooth, mild and selective condensation with α-methylene ketones on the surface of silver heteropoly acid (Ag₃PW₁₂O₄₀) to afford the corresponding polysubstituted quinolines in excellent yields. The catalyst can be recovered by simple filtration and can be recycled.

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Key Words

heteropoly acids, o-aminoaryl ketones, α-methylene ketones, quinolines, Friedländer synthesis

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ID: J66-Y2004-2350