Novel Synthetic Strategy of N-Arylated Heterocycles via Sequential Palladium-Catalyzed Intra- and Inter-Arylamination Reactions
Rafik Omar-Amrani, Raphaël Schneider*, Yves Fort*
*Synthèse Organométallique et Réactivité, UMR CNRS-UHP 7565, Faculté des
Sciences, BP 239, 54506 Vandoeuvre les Nancy Cedex, France, Email:
Raphael.Schneider
sor.uhp-nancy.fr, Yves.Fortsor.uhp-nancy.fr
R. Omar-Amrani, R. Schneider, Y. Fort, Synthesis, 2004, 2527-2534.
DOI: 10.1055/s-2004-831205
Abstract
The use of N,N′-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and tBuONa as the base for sequential palladium-catalyzed intra- followed by intermolecular aryl amination enables the synthesis of N-arylated five-, six- and seven-membered nitrogen heterocycles.
see article for more examples
Key Words
palladium catalyst, N-heterocyclic carbene ligand, aryl amination reaction, N-arylated heterocycles, benzo-fused N-Heterocycles, indolines, Buchwald-Hartwig coupling
ID: J66-Y2004-2370
