A palladium catalyzed efficient synthesis of γ-methylene-α,β-unsaturated γ-lactones via cyclization of 3,4-alkadienoic acids

Shengming Ma* and Fei Yu

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China, Email: masmmail.sioc.ac.cn

S. Ma, F. Yu, Tetrahedron, 2005, 61, 9896-9901.

DOI: 10.1016/j.tet.2005.06.063

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Abstract

γ-Methylene-α,β-unsaturated γ-lactones were efficiently synthesized by a Pd-catalyzed cyclization of 3,4-alkadienoic acids. The use of a N₂ atmosphere ensures a high purity of the products.

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Key Words

3,4-Alkadienoic acids, Palladium, CuCl₂, Cyclization, Butenolides

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ID: J72-Y2005-3100