Organic Chemistry Portal



Phosphorodiamidic Acid as a Novel Structural Motif of Brønsted Acid Catalysts for Direct Mannich Reaction of N-Acyl Imines with 1,3-Dicarbonyl Compounds

Masahiro Terada*, Keiichi Sorimachi, Daisuke Uraguchi

*Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan, Email:

M. Terada, K. Sorimachi, D. Uraguchi, Synlett, 2006, 133-136.

DOI: 10.1055/s-2005-922783

see article for more reactions


Achiral and chiral phosphorodiamidic acids were developed as efficient Brønsted acid catalysts for the direct Mannich reaction of N-acyl imines with 1,3-dicarbonyl compounds.

see article for more examples

Key Words

organocatalysis, Mannich reaction, active methylene compounds, green chemistry, asymmetric catalysis, imines

ID: J60-Y2006-4190