A New and Efficient Method for the Trifluoromethylation of Carbonyl Compounds with Trifluoromethyltrimethylsilane in DMSO
Katsuyuki Iwanami, Takeshi Oriyama*
*Faculty of Science, Ibaraki University, 2-1-1 Bunkyo, Mito 310-8512, Japan, Email:
tor
mx.ibaraki.ac.jp
K. Iwanami, T. Oriyama, Synlett, 2006, 112-114.
DOI: 10.1055/s-2005-922767
Abstract
In the presence of molecular sieves in DMSO, trifluoromethylation of various aldehydes and ketones with trifluoromethyltrimethylsilane proceeded very smoothly to give the corresponding trifluoromethylated adduct in good to quantitative yields without a base catalyst.
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Key Words
trifluoromethylation, trifluoromethyltrimethylsilane, carbonyl compounds, alcohols, DMSO
ID: J60-Y2006-4220
