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Practical Oppenauer (OPP) Oxidation of Alcohols with a Modified Aluminium Catalyst

Takashi Ooi, Hidehito Otsuka, Tomoya Miura, Hayato Ichikawa and Keiji Maruoka*

*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Email: maruokakuchem.kyoto-u.ac.jp

T. Ooi, H. Otshuka, T. Miura, H. Ichikawa, K. Maruoka, Org. Lett., 2002, 4, 2669-2672.

DOI: 10.1021/ol020094c (free Supporting Information)


Abstract

An effective protocol for Oppenauer (OOP) oxidation of alcohols under mild conditions with t-BuCHO as hydride acceptor was developed. The highly active aluminium catalyst allowed even the oxidation of terpenoids and stereoids with acetone as the hydride acceptor.

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Key Words

Oppenauer Oxidation, Meerwein-Ponndorf-Verley Reduction, Pivaldehyde, Acetone


ID: J54-Y2002-500