Facile Generation of a Library of 5-Aryl-2-arylsulfonyl-1,3-thiazoles
Peter W. Sheldrake*, Mizio Matteucci, Edward McDonald*
*Medicinal Chemistry Team, The Cancer Research UK Centre for Cancer
Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Belmont,
Sutton, Surrey SM2 5NG, UK, Email: peter.sheldrake
icr.ac.uk,
ted.mcdonaldicr.ac.uk
P. W. Sheldrake, M. Matteucci, E. McDonald, Synlett, 2006, 460-462.
DOI: 10.1055/s-2006-926243
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Abstract
Treatment of N,N-diformylaminomethyl aryl ketones with phosphorus pentasulfide and triethylamine in chloroform gives 5-arylthiazoles in good yield. The 5-aryl-1,3-thiazole core has been successfully functionalised at the 2-position to yield, over two steps, a large array of 5-aryl-2-arylsulfonyl-1,3-thiazoles.
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Key Words
heterocycles, 1,3-thiazoles, phosphorus pentasulfide
ID: J60-Y2006-4270
