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Three-component indole synthesis using ortho-dihaloarenes

Ludwig T. Kaspar and Lutz Ackermann

*Institut fuer Organische und Biomolekulare Chemie, Georg-August-Universitaet Goettingen, Tammannstr. 2, 37077 Goettingen, Germany, Email:

L. T. Kaspar, L. Ackermann, Tetrahedron, 2005, 61, 11311-11316.

DOI: 10.1016/j.tet.2005.09.095


A three-component synthesis of substituted indoles starts from ortho-dihaloarenes through the use of a multicatalytic system consisting of an N-heterocyclic carbene palladium complex and CuI. Indole derivatives are obtained as single regioisomers in high yields.

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Key Words

Indoles, Multi-catalytic reaction, Sonogashira Coupling, Buchwald-Hartwig Coupling

ID: J72-Y2005-3170