A New Synthesis of Butadienyl- and Styrylboronic Esters: Highly Reactive Intermediates for Suzuki Cross-Coupling
Paolo Balma Tivola, Annamaria Deagostino, Cristina Prandi and Paolo Venturello*
*Dipartimento di Chimica Generale ed Organica Applicata dell'Università,
Corso Massimo D'Azeglio, 48, I 10125 Torino, Italy, Email:
paolo.venturello
unito.it
P. B. Tivola, A. Deagostino, C. Prandi, P. Venturello, Org. Lett., 2002, 4, 1275-1277.
DOI: 10.1021/ol0255817
Abstract
A new method for the synthesis of organoborates starting from α,β-unsaturated acetals was developed. The available alkoxy-functionalized butadienyl- and styrylboronic esters cross couple effectively with a broad spectrum of aryl halides under mild conditions. This method provides an effective approach to aromatic ketones.
see article for more examples
see article for more reactions
see article for more examples
Key Words
Suzuki Coupling, Boronates, Aromatic Ketones, Enones
ID: J54-Y2002-600
