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The Arndt-Eistert Reaction in Peptide Chemistry: A Facile Access to Homopeptides

Joachim Podlech, Dieter Seebach*

*Laboratory of Organic Chemistry, Wolfgang-Paulistrasse 10, HCI H331, 8093 Zuerich, Switzerland, Email: seebachorg.chem.ethz.ch

J. Podlech, D. Seebach, Angew. Chem. Int. Ed., 1995, 34, 471-472.

DOI: 10.1002/anie.199504711


Abstract

The chain extension of carboxylic acids developed by Arndt and Eistert was applied to the construction of peptides containing β-amino acids. The method may be used for the generation of new types of peptide-containing combinatorial libraries.

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Key Words

Arndt-Eistert synthesis, β-amino acids, diazoketones, dihydrooxazinones, homopeptides, peptide analogues


ID: J06-Y1995-540