Mild and regioselective iodination of electron-rich aromatics with N-iodosuccinimide and catalytic trifluoroacetic acid
Anne-Sophie Castanet, Françoise Colobert* and Pierre-Emmanuel Broutin
*Laboratoire de stéréochimie associé au CNRS, URA 7509, Université Louis Pasteur, ECPM, 25 rue Becquerel, 67087, Strasbourg Cedex 2, France, Email: fcoloberchimie.u-strasbg.fr
A.-S. Castanet, F. Colobert, P.-E. Broutin, Tetrahedron Lett., 2002, 43, 5047-5048.
Various methoxy- or methyl-substituted aromatic compounds were regioselectively iodinated with N-iodosuccinimide and and a catalytic amount of trifluoroacetic acid with excellent yields under mild conditions and short reaction times.
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