A Mild and Facile Method for Complete Hydrogenation of Aromatic Nuclei in Water

Tomohiro Maegawa, Akira Akashi, Hironao Sajiki*

*Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Gifu 502-8585, Japan, Email: sajikigifu-pu.ac.jp

T. Maegawa, A. Akashi, H. Sajiki, Synlett, 2006, 1440-1442.

DOI: 10.1055/s-2006-939719

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Abstract

A mild, complete hydrogenation of aromatic rings catalyzed by heterogeneous 10% Rh/C proceeds at 80 °C in water under 5 atm of H₂ pressure and is applicable to the hydrogenation of various carbon and heteroaromatic compounds such as alkylbenzenes, biphenyls, pyridines and furans.

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Key Words

hydrogenation, hydrogen, aromatic ring, piperidines, tetrahydrofurans, heterogeneous catalyst, rhodium, water

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ID: J60-Y2006-4430