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A Mild and Facile Method for Complete Hydrogenation of Aromatic Nuclei in Water

Tomohiro Maegawa, Akira Akashi, Hironao Sajiki*

*Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Gifu 502-8585, Japan, Email: sajikigifu-pu.ac.jp

T. Maegawa, A. Akashi, H. Sajiki, Synlett, 2006, 1440-1442.

DOI: 10.1055/s-2006-939719


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Abstract

A mild, complete hydrogenation of aromatic rings catalyzed by heterogeneous 10% Rh/C proceeds at 80 C in water under 5 atm of H2 pressure and is applicable to the hydrogenation of various carbon and heteroaromatic compounds such as alkylbenzenes, biphenyls, pyridines and furans.



Key Words

hydrogenation, hydrogen, aromatic ring, piperidines, tetrahydrofurans, heterogeneous catalyst, rhodium, water


ID: J60-Y2006-4430