A Novel, One-Pot, Three-Component Synthesis of 1,2,4-Oxadiazoles under Microwave Irradiation and Solvent-Free Conditions
Mehdi Adib*, Mohammad Mahdavi, Niusha Mahmoodi, Hooshang Pirelahi, Hamid Reza Bijanzadeh
*School of Chemistry, University College of Science, University of Tehran,
Tehran, Iran, Email: madib
khayam.ut.ac.ir
M. Adib, M. Mahdavi, N. Mahmoodi, H. Pirelahi, H. R. Bijanzadeh, Synlett, 2006, 1765-1767.
Abstract
A one-pot reaction between nitriles, hydroxylamine and Meldrum’s acids under microwave irradiation and solvent-free conditions gives 3,5-disubstituted 1,2,4-oxadiazoles in good to excellent yields.
see article for more examples
proposed mechanism
Key Words
Meldrum’s acids, nitriles, 1,2,4-oxadiazoles, solvent-free synthesis, microwave synthesis
ID: J60-Y2006-4550
