New and easy route to primary cyclopropylamines from nitriles
Philippe Bertus and Jan Szymoniak*
*Réactions Sélectives et Applications, CNRS and Université de Reims, 51687
Reims Cedex 2, France, Email: jan.szymoniak
univ-reims.fr
P. Bertus, J. Szymoniak, Chem. Commun., 2001, 1792-1793.
DOI: 10.1039/b105293b
Abstract
Starting from readily available substrates, a new synthesis of primary cyclopropylamines involves a cooperative Ti(II)- and Lewis acid-mediated coupling of alkanenitriles with Grignard reagents.
see article for more examples
proposed mechanism
A Direct Synthesis of 1-Aryl- and 1-Alkenylcyclopropylamines from Aryl and Alkenyl Nitriles
P. Bertus, J. Szymoniak, J. Org. Chem., 2003, 68, 7133-7136.
Key Words
Kulinkovich-Szymoniak Reaction, Cyclopropylamines, Alkylamines
ID: JXX-Y2001-640
