Unexpected Highly Efficient Ring-Opening of Aziridines or Epoxides with Iodine Promoted by Thiophenol

Jie Wu*, Xiaoyu Sun, Wei Sun, Shengqing Ye

*Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, P. R. of China, Email: jie_wufudan.edu.cn

J. Wu, X. Sun, W. Sun, S. Ye, Synlett, 2006, 2489-2491.

DOI: 10.1055/s-2006-950417

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Abstract

An efficient and mild thiophenol-promoted ring-opening of aziridines or epoxides with iodine afforded β-iodo amines or β-iodo alcohols in very good yields.

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Key Words

aziridines, epoxides, iodine, iodohydrins, 1,2-iodoamines, thiophenol, ring-opening

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ID: J60-Y2006-4640