A Convenient Route to 3-Pyrroline Utilizing the DelÚpine Reaction
Svante Brandńnge*, Benito Rodriguez
*Department of Organic Chemistry, Arrhenius Laboratory, University of Stockholm, S-10691 Stockholm, Sweden, Email: svanteorgan.su.se
S. Brandńnge, B. Rodriquez, Synthesis, 1988, 347-348.
3-Pyrroline has been prepared from (Z)-1,4-dichloro-2-butene in three steps in an overall yield of 74%. The DelÚpine Reaction permitted the monoamination of the substrate in practically quantitative yields. The subsequent ring-closing reaction was less efficient.