Organic Chemistry Portal

Abstracts

Search:

Novel Method for Incorporating the CHF2 Group into Organic Molecules Using BrF3

Revital Sasson, Aviv Hagooly and Shlomo Rozen*

*School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel, Email: rozenspost.tau.ac.il 

R. Sasson, A. Hagooly, S. Rozen, Org. Lett., 2003, 5, 3635-3641.

DOI: 10.1021/ol034051n (free Supporting Information)


Abstract

Easily prepared 2-alkyl-1,3-dithiane derivatives were reacted with BrF3 to form the corresponding 1,1-difluoromethyl alkanes in good yield. The reaction proceeds well with primary alkyl halides. The limiting step for secondary alkyl halides is the relatively low yield of the dithiane preparation.

see article for more reactions

reactions of oxathioacetals and acetals



Key Words

Dithianes, Difluoroalkanes


ID: J54-Y2003-330