Novel Class of Tertiary Phosphine Ligands Based on a Phospha-adamantane Framework and Use in the Suzuki Cross-Coupling Reactions of Aryl Halides under Mild Conditions
George Adjabeng, Tim Brenstrum, Jeffrey Wilson, Christopher Frampton, Al Robertson, John Hillhouse, James McNulty and Alfredo Capretta*
*Institute of Molecular Catalysis, Department of Chemistry, Brock
University, St. Catharines, Ontario L2S 3A1, Canada, Email:
fcaprett
chemiris.labs.brocku.ca
G. Adjabeng, T. Brenstrum, J. Wilson, C. Frampton, A. Robertson, J. Hillhouse, J. McNulty, A. Capretta, Org. Lett., 2003, 5, 953-955.
DOI: 10.1021/ol0341647 (free Supporting Information)
Abstract
A catalytic system incorporating Pd2(dba)3 and 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phenyl-6-phospha-adamantane as sterically hindered phosphine ligand promotes the Suzuki cross-coupling of aryl iodides, bromides, and activated chlorides with various aryl boronic acids at room temperature in a few hours with high yields.
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E. Awuah, A. Capretta, Org. Lett., 2009, 11, 3210-3213.
Key Words
ID: J54-Y2003-360
