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Microwave-Assisted Synthesis of Diaryl Ethers without Catalyst

Feng Li, Quanrui Wang,* Zongbiao Ding, and Fenggang Tao

*Department of Chemistry, Fudan University, 200433 Shanghai, P. R. China, Email: qrwangbonline.sh.cn

F. Li, Q. Wang, Z. Ding, G. Tao, Org. Lett., 2003, 5, 2169-2171.

DOI: 10.1021/ol0346436 (free Supporting Information)


Abstract

Catalyst-free direct coupling of phenols to electron-deficient aryl halides through SNAr-based addition reactions gave diaryl ethers in very good yields within 5-10 min  in refluxing DMSO with assistance of microwave irradiation.

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Key Words

Diaryl Ethers, Phenols, Microwave Synthesis


ID: J54-Y2003-410