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An Effective Synthesis of α-Cyanoenamines by Peterson Olefination

Waldemar Adam, Claudio M. Ortega-Schulte*

*Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany, Email: adamchemie.uni-wuerzburg.de

W. Adam, C. M. Ortega-Schulte, Synlett, 2003, 414-416.

DOI: 10.1055/s-2003-37119


Abstract

A convenient and gentle method for the synthesis of α-cyanoenamines based on the Peterson olefination has been developed. For these sensitive, highly functionalized olefins, the present method is superior to the Horner-Emmons condensation, as manifested by the higher yields and broader scope.

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Key Words

α-Cyanoenamines, Peterson Olefination, Horner-Emmons condensation


ID: J60-Y2003-520