Anti-Markovnikov Hydroamination of Terminal Alkynes
Annegret Tillack, Ivette Garcia Castro, Christian G. Hartung, Matthias Beller*
*Institut für Organische Katalyseforschung (IfOK) Universität Rostock e.V.
Buchbinderstraße 5-6, 18055 Rostock (Deutschland), Email:
Matthias.Beller
catalysis.de
A. Tillack, I. G. Castro, C. G. Hartung, M. Beller, Angew. Chem. Int. Ed., 2002, 41, 2541-2543.
DOI: 10.1002/1521-3773(20020715)41:14<2541::AID-ANIE2541>3.0.CO;2-7
Abstract
Readily available and stable titanocene-alkyne complexes can be used for the hydroamination of internal and terminal alkynes. The reactions of terminal alkynes with aliphatic amines proceed highly selectively to give the corresponding primary anti-Markovnikov functionalized imines in good to excellent yields.
see article for more examples
A Convenient Rhodium-Catalyzed Intermolecular Hydroamination Procedure for Terminal Alkynes
C. G. Hartung, A. Tillack, H. Trauthwein, M. Beller, J. Org. Chem., 2001, 66, 6339-6343.
Key Words
alkynes, homogeneous catalysis, hydroamination, metallocenes, titanium, imines
ID: J06-Y2002-760
