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An Improved Protocol for the RuO4-Catalyzed Dihydroxylation of Olefins

Bernd Plietker* and Meike Niggemann

*Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany, Email:

B. Plietker, M. Niggemann, Org. Lett., 2003, 3353-3356.

DOI: 10.1021/ol035335a (free Supporting Information)


An improved protocol for the RuO4-catalyzed syn-dihydroxylation uses only 0.5 mol% catalyst under acidic conditions. Various olefins can be hydroxylated in good to excellent yields with only minor formation of side products.

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proposed mechanism

The acid accelerated ruthenium-catalysed dihydroxylation. Scope and limitations

B. Plietker, M. Niggemann, A. Pollrich, Org. Biomol. Chem., 2004, 2, 1116-1124. DOI: 10.1039/b316546a

Key Words

Dihydroxylation, Ruthenium, Sodium Periodat

ID: J54-Y2003-540