An Efficient and Catalytically Enantioselective Route to (S)-(-)-Phenyloxirane
E. J. Corey*, S. Shibata, R. K. Bakshi
*Department of Chemistry and Chemical Biology, Harvard
University, Cambridge, Massachusetts 02138, Email: corey
chemistry.harvard.edu
E. J. Corey, S. Shibata, R. K. Bakshi, J. Org, Chem., 1988, 53, 2861-2863.
DOI: 10.1021/jo00247a044
Abstract
Key step in the synthesis of chiral phenyloxirane is the enantioselective catalytic reduction of an achiral chloromethyl ketone by means of a chiral oxazaborolidine as catalyst and borane as stoichiometric reductant.
Key Words
Corey-Bakshi-Shibata Reduction, Epoxides, Borane
ID: J42-Y1988-010
