An Efficient and Catalytically Enantioselective Route to (S)-(-)-Phenyloxirane
E. J. Corey*, S. Shibata, R. K. Bakshi
*Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Email: coreychemistry.harvard.edu
E. J. Corey, S. Shibata, R. K. Bakshi, J. Org, Chem., 1988, 53, 2861-2863.
Key step in the synthesis of chiral phenyloxirane is the enantioselective catalytic reduction of an achiral chloromethyl ketone by means of a chiral oxazaborolidine as catalyst and borane as stoichiometric reductant.