Organic Chemistry Portal

Abstracts

Search:

A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst

Yongcun Shen, Xiaoming Feng*, Yan Li, Guolin Zhang and Yaozhong Jiang

*Sichuan Key Laboratory of Green Chemistry and Technology, College of Chemistry, Sichuan University, Chengdu 610064, People's Republic of, China, Email: xmfengpridns.scu.edu.cn

Y. Shen, X. Feng, Y. Li, G. Zhang, Y. Jiang, Tetrahedron, 2003, 59, 5667-6675.

DOI: 10.1016/S0040-4020(03)00908-6


Abstract

Combinations of N-oxides and Ti(OiPr)4 act as bifunctional catalysts in the cyanosilylation of ketones. The reaction is promoted by the dual action of these new titanium complexes via activation of the ketone by the titanium and of TMSCN by the N-oxide.

     see article for more examples



Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins

F.-X. Chen, X. Liu, B. Qin, H. Zhou, X. Feng, G. Zhang, Synthesis, 2004, 2266-2272.


Key Words

Lewis acid, Lewis base, catalyst, cyanosilylation, ketone 


ID: J72-Y2003-600