Carbonylative Sonogashira Coupling of Terminal Alkynes with Aqueous Ammonia

Mohamed S. Mohamed Ahmed and Atsunori Mori*

*Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8503, Japan, Email: amorires.titech.ac.jp

M. S. M. Ahmed, A. Mori, Org. Lett., 2003, 5, 3057-3060.

DOI: 10.1021/ol035007a (free Supporting Information)

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Abstract

Carbonylative coupling of terminal alkynes with aryliodides in the presence of PdCl₂(PPh₃)₂ as catalyst, 2 eq. of 0.5 M aqueous ammonia, and CO (1 atm) gives the corresponding α,β-alkynyl ketones in good yields.

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Key Words

Carbonylative Coupling, Palladium Catalysis, Multicomponent Reactions, Propargyl Ketones, Aryl Ketones

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ID: J54-Y2003-620