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Tweaking Copper Hydride (CuH) for Synthetic Gain. A Practical, One-Pot Conversion of Dialkyl Ketones to Reduced Trialkylsilyl Ether Derivatives

Bruce H. Lipshutz,* Christopher C. Caires, Peter Kuipers and Will Chrisman

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, Email: lipshutzchem.ucsb.edu

B. H. Lipshutz, C. C. Caires, P. Kuipers, W. Chrisman, Org. Lett., 2003, 5, 3085-3088.

DOI: 10.1021/ol035164+ (free Supporting Information)


Abstract

Optimizations to generate CuH in situ have led to an efficient and inexpensive hydrosilylation method for dialkyl ketones.

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Copper(I) Hydride-Catalyzed Asymmetric Hydrosilylation of Heteroaromatic Ketones

B. H. Lipshutz, A. Lower, K. Noson, Org. Lett., 2002, 4, 4045-4048.


Key Words

Silyl Ethers, Ketones, Reductions, Copper Hydride, Triethylsilane


ID: J54-Y2003-670