Synthesis of tertiary α-amino phosphonate by one-pot three-component coupling mediated by LPDE
Najmedin Azizi and Mohammad R. Saidi*
*Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516, Tehran, Iran, Email: saidisharif.edu
N. Azizi, M. R. Saidi, Tetrahedron, 2003, 59, 5329-5332.
A new, very mild, efficient and simple method for the preparation of tertiary α-amino phosphonates is reported. The reaction of an aldehyde, a secondary amine and trialkylphosphite in ethereal solution of lithium perchlorate (LPDE) at ambient temperature gives the desired product in high yields.
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