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Green Protocol for Conjugate Addition of Thiols to α,β-Unsaturated Ketones Using a [Bmim]PF6/H2O System

J. S. Yadav*, B. V. S. Reddy and Gakul Baishya

Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email:

J. S. Yadav, B. V. S. Reddy, G. Baishya, J. Org. Chem., 2003, 68, 7098-7100.

DOI: 10.1021/jo034335l


A rapid conjugate addition of thiols to α,β-unsaturated ketones is achieved in a hydrophobic ionic liquid [bmim]PF6/H2O solvent system in the absence of any acid catalyst. This mild and neutral method gave the corresponding Michael adducts in high yields with excellent 1,4-selectivity. The ionic liquid can be reused.

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Key Words

1,4-addition, arylsulfides, ionic liquids, green chemistry

ID: J42-Y2003-730