Green Protocol for Conjugate Addition of Thiols to α,β-Unsaturated Ketones Using a [Bmim]PF6/H2O System
J. S. Yadav*, B. V. S. Reddy and Gakul Baishya
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email: yadavpubiict.res.in
J. S. Yadav, B. V. S. Reddy, G. Baishya, J. Org. Chem., 2003, 68, 7098-7100.
A rapid conjugate addition of thiols to α,β-unsaturated ketones is achieved in a hydrophobic ionic liquid [bmim]PF6/H2O solvent system in the absence of any acid catalyst. This mild and neutral method gave the corresponding Michael adducts in high yields with excellent 1,4-selectivity. The ionic liquid can be reused.
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