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Oxone Promoted Nef Reaction. Simple Conversion of Nitro Group into Carbonyl

Paolo Ceccherelli, Massimo Curini, Maria Carla Marcotullio*, Francesco Epifano and Ornelio Rosati

*Diparimento di Chimica e Tecnologia del Farmaco-Sez. Chimica Organica, UniversitÓ degli Studi, Via del liceo, 1, 06123 Perugia-Italy, Email: marcotuunipg.it

P. Ceccherelli, M. Curini, M. C. Marcotullio, F. Epifano, O. Rosati, Synth. Commun., 1998, 28, 3057-3064.

DOI: 10.1080/00397919808004885


Abstract

A mild and convenient oxidative Nef reaction using Oxone is described. Following this procedure primary and secondary nitroalkanes generates carboxylic acids and ketones, respectively, both in good yields.

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proposed mechanism



Key Words

Nitro Compounds, Ketones, Nef Reaction, Oxone


ID: JXX-Y1998-230