ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis
Erik Årstad, Anthony G. M. Barrett,* Brian T. Hopkins and Johannes Köbberling
*Department of Chemistry, Imperial College of Science, Technology and
Medicine, London SW7 2AY, United Kingdom, Email: agmb
ic.ac.uk
E. Arstad, A. G. M. Barrett, B. T. Hopkins, J. Koebberling, Org. Lett., 2002, 4, 1975-1977.
DOI: 10.1021/ol026008q
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Abstract
ROMPGel-supported triphenylphosphine was synthesized in three steps from norbornadiene, 4-bromoiodobenzene, and chlorodiphenylphosphine. The supported reagent has a high loading (2.5 mmol/g) and swells in organic solvents. It has been utilized for the conversion of alcohols to halides, the reduction of ozonides, and the isomerization of α,β-acetylenic esters and in the Staudinger reaction.
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preparation of ROMPGel-supported triphenylphosphine
Key Words
ROMP, Appel Reaction, Staudinger Reaction
ID: J54-Y2002-820
