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ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis

Erik ┼rstad, Anthony G. M. Barrett,* Brian T. Hopkins and Johannes K÷bberling

*Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, United Kingdom, Email: agmbic.ac.uk

E. Arstad, A. G. M. Barrett, B. T. Hopkins, J. Koebberling, Org. Lett., 2002, 4, 1975-1977.

DOI: 10.1021/ol026008q


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Abstract

ROMPGel-supported triphenylphosphine was synthesized in three steps from norbornadiene, 4-bromoiodobenzene, and chlorodiphenylphosphine. The supported reagent has a high loading (2.5 mmol/g) and swells in organic solvents. It has been utilized for the conversion of alcohols to halides, the reduction of ozonides, and the isomerization of α,β-acetylenic esters and in the Staudinger reaction.


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preparation of ROMPGel-supported triphenylphosphine



Key Words

ROMP, Appel Reaction, Staudinger Reaction


ID: J54-Y2002-820