Conversion of alcohols to bromides using a fluorous phosphine
Laurence Desmaris, Nathalie Percina, Louis Cottier and Denis Sinou*
*Laboratoire de Synthèse Asymétrique, associé au CNRS, Université Claude
Bernard Lyon 1, CPE Lyon, 43, boulevard du 11 novembre 1918, 69622, Villeurbanne
cédex, France, Email: sinou
univ-lyon1.fr
L. Desmaris, N. Percina, L. Cottier, D. Sinou, Tetrahedron Lett., 2003, 44, 7589-7591.
DOI: 10.1016/j.tetlet.2003.08.064
Abstract
Appel reactions of alcohols with fluorous phosphine-carbon tetrabromide in toluene or in a biphasic toluene-FC-72 system afforded the corresponding bromides in good yields. Simple liquid-liquid extraction separates the fluorous-phosphine oxide from the product.
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Key Words
fluorous triphenylphosphine, tetrabromomethane, fluorous solvent, recycling, Appel Reaction
ID: J72-Y2003-830
