Titanocene(III)-Promoted Reformatsky Additions
J. D. Parrish, Daniel R. Shelton and R. Daniel Little*
*Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, California 93106-9510, Email: littlechem.ucsb.edu
J. D. Parrish, D. R. Shelton, R. D. Little, Org. Lett., 2003, 5, 3615-3617.
A novel method for Reformatsky-like reactions employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are simple, rapid and tolerate a wide range of functionalities. The addition is anti selective.
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