Novel Synthesis of 2-Oxo-3-butynoates by Copper-Catalyzed Cross-Coupling Reaction of Terminal Alkynes and Monooxalyl Chloride
Minjie Guo, Dao Li and Zhaoguo Zhang*
*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of
Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032,
People's Republic of China, Email: zhaoguo
mail.sioc.ac.cn
M. Guo, D. Li, Z. Zhang, J. Org. Chem., 2003, 68, 10172-10174.
DOI: 10.1021/jo0353076 (free Supporting Information)
Abstract
2-Oxo-3-butynoates and 2-oxo-3-butynoamides were synthesized by a general, efficient and mild Cu(I)-catalyzed cross-coupling of terminal alkynes and monooxalyl chloride derivatives. Readily available starting materials, mild reaction conditions, wide functional group tolerance, and the obviation of stoichiometric organometallic reagents combine to highlight this reaction.
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Key Words
Copper, Catalysis, Cross Coupling, Propargyl Ketones
ID: J42-Y2003-1040
